Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0XJ6C
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| Former ID |
DIB006185
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| Drug Name |
DIAPLASININ
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| Synonyms |
Diaplasinin < USAN; PAI-749; Prop INN >; 1-Benzyl-3-pentyl-2-[6-(1H-tetrazol-5-ylmethoxy)naphthalen-2-yl]-1H-indole
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| Drug Type |
Small molecular drug
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| Indication | Thrombolysis [ICD9: 410, 415.1, 434.91, 459.9; ICD10:I21-I22, I26, I61-I63, I99.9] | Phase 1 | [530810] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C32H31N5O
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| Canonical SMILES |
CCCCCc1c(c2ccc3cc(OCc4nnn[nH]4)ccc3c2)n(Cc5ccccc5)c6ccc<br />cc16
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| InChI |
1S/C32H31N5O/c1-2-3-5-13-29-28-12-8-9-14-30(28)37(21-23-10-6-4-7-11-23)32(29)26-16-15-25-20-27(18-17-24(25)19-26)38-22-31-33-35-36-34-31/h4,6-12,14-20H,2-3,5,13,21-22H2,1H3,(H,33,34,35,36)
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| InChIKey |
BDPXZFKVHDEPIQ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Plasminogen activator inhibitor-1 | Target Info | Inhibitor | [530810], [531635] | |
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| p73 transcription factor network | |||||
| E2F transcription factor network | |||||
| HIF-2-alpha transcription factor network | |||||
| Direct p53 effectors | |||||
| Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||||
| HIF-1-alpha transcription factor network | |||||
| WikiPathways | Senescence and Autophagy in Cancer | ||||
| TGF Beta Signaling Pathway | |||||
| Complement and Coagulation Cascades | |||||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | |||||
| Blood Clotting Cascade | |||||
| Extracellular matrix organization | |||||
| Oncostatin M Signaling Pathway | |||||
| Adipogenesis | |||||
| Dissolution of Fibrin Clot | |||||
| Circadian Clock | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| Ref 530810 | Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost. 2010 Jun;8(6):1333-9. | ||||
| Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
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