Drug Information

Drug General Information
Drug ID
D0Y1NC
Former ID
DIB016020
Drug Name
CHS-828
Synonyms
Cancer therapeutics, LEO Pharma; GMX-1778
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1/2 [529259]
Company
LEO Pharma A/S
Structure
Download
2D MOL

3D MOL
Formula
C19H22ClN5O
Canonical SMILES
N(=C(\Nc1ccncc1)/NCCCCCCOc1ccc(Cl)cc1)/C#N
CAS Number
CAS 200484-11-3
PubChem Compound ID
148198
Target and Pathway
Target(s) Nicotinamide phosphoribosyltransferase Target Info Inhibitor [529259], [532983]
BioCyc Pathway NAD salvage
KEGG Pathway Nicotinate and nicotinamide metabolism
Metabolic pathways
NetPath Pathway IL2 Signaling Pathway
IL1 Signaling Pathway
TCR Signaling Pathway
PathWhiz Pathway Nicotinate and Nicotinamide Metabolism
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Adipogenesis
Metabolism of water-soluble vitamins and cofactors
Circadian Clock
References
Ref 529259Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804.
Ref 529259Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804.
Ref 532983Structural basis for resistance to diverse classes of NAMPT inhibitors. PLoS One. 2014 Oct 6;9(10):e109366.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.