Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Y5IH
|
||||
| Former ID |
DNCL002347
|
||||
| Drug Name |
MPDL-3280A
|
||||
| Company |
Genentech
|
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| Target and Pathway | |||||
| Target(s) | Programmed cell deathe?Y? ligand 1 (PD-L1) | Target Info | Modulator | [544402] | |
| KEGG Pathway | Cell adhesion molecules (CAMs) | ||||
| Reactome | PD-1 signaling | ||||
| WikiPathways | Costimulation by the CD28 family | ||||
| References | |||||
| Ref 525141 | ClinicalTrials.gov (NCT02409355) A Study of MPDL3280A Compared With Gemcitabine + Cisplatin or Carboplatin in Patients With Stage IV Squamous Non-Small Cell Lung Cancer. U.S. National Institutes of Health. | ||||
| Ref 542904 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7990). | ||||
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