Drug General Information
Drug ID
D0Y7DP
Former ID
DNC001491
Drug Name
Uridine
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [467803], [521713]
Structure
Download
2D MOL

3D MOL

Formula
C9H12N2O6
InChI
InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChIKey
DRTQHJPVMGBUCF-XVFCMESISA-N
CAS Number
CAS 322-35-0
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:16704
Target and Pathway
Target(s) Thymidine phosphorylase Target Info Inhibitor [536519]
BioCyc Pathway Pyrimidine deoxyribonucleosides degradation
KEGG Pathway Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Bladder cancer
NetPath Pathway TSH Signaling Pathway
PathWhiz Pathway Pyrimidine Metabolism
WikiPathways Bladder Cancer
Metabolism of nucleotides
Fluoropyrimidine Activity
References
Ref 467803(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4566).
Ref 521713ClinicalTrials.gov (NCT00210080) A Study to Diagnose Lung Cancer by Sputum Cytology (01-312). U.S. National Institutes of Health.
Ref 536519Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10.

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