Drug Information

Drug General Information
Drug ID
D0Y7YD
Former ID
DIB006364
Drug Name
SMT-C1100
Synonyms
BMN-195; SMT-C1100; Utrophin modulators (Duchenne muscular dystrophy); VOXC-1100; Utrophin modulators (Duchennemuscular dystrophy), VASTox; Utorphin upregulators (Duchenne muscular dystrophy), VASTox/University of Oxford; Utrophin modulators (Duchenne muscular dystrophy), Summit/BioMarin; Utropine inducer (Duchenne muscular dystrophy), Summit/BioMarin
Drug Type
Small molecular drug
Indication Duchenne muscular dystrophy [ICD10:G71.0] Phase 1 [525109]
Company
Summit Corp plc
Structure
Download
2D MOL

3D MOL
Formula
C19H15NO3S
Canonical SMILES
O=S(=O)(c1ccc2oc(nc2c1)c1ccc2c(c1)cccc2)CC
PubChem Compound ID
25109292
Target and Pathway
Target(s) Utrophin Target Info Regulator (upregulator) [533130]
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 525109ClinicalTrials.gov (NCT02383511) Modified Diet Trial: A Study of SMT C1100 in Paediatric Patients With DMD Who Follow a Balanced Diet. U.S. National Institutes of Health.
Ref 533130Safety, tolerability, and pharmacokinetics of SMT C1100, a 2-arylbenzoxazole utrophin modulator, following single- and multiple-dose administration to healthy male adult volunteers. J Clin Pharmacol.2015 Jun;55(6):698-707.

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