Drug Information

Drug General Information
Drug ID
D0YA7R
Former ID
DIB020348
Drug Name
MeTRH
Synonyms
His(1-methyl)-TRH; His(1-methyl)-thyrotropin-releasing hormone; pGlu-His(1(t)-methyl)-ProNH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539355]
Structure
Download
2D MOL
Formula
C17H24N6O4
InChI
InChI=1S/C17H24N6O4/c1-22-13(4-5-14(22)24)16(26)21-11(7-10-8-19-9-20-10)17(27)23-6-2-3-12(23)15(18)25/h8-9,11-13H,2-7H2,1H3,(H2,18,25)(H,19,20)(H,21,26)/t11-,12-,13-/m0/s1
InChIKey
DJLHRAHTTSWYAW-AVGNSLFASA-N
PubChem Compound ID
5311291
PubChem Substance ID
7979977, 39340990, 52482428, 57359420, 114155757, 135650600, 135651176, 162503022
Target and Pathway
Target(s) Thyrotropin-releasing hormone receptor Target Info Agonist [533507]
TRH2 receptor Target Info Agonist [532186]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Thyrotropin-releasing hormone receptor signaling pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539355(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2137).
Ref 532186Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice. Neuropsychopharmacology. 2013 May;38(6):950-6.
Ref 533507Synthetic TRF (thyrotropin releasing factor) analogues. II. pGlu-N3imMe-His-Pro-NH2: a synthetic analogue with specific activity greater than that of TRF2. Endocrinology. 1971 Dec;89(6):1485-8.

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