Drug Information

Drug General Information
Drug ID
D0YG4P
Former ID
DNCL002372
Drug Name
Anti-OX40 mab
Drug Type
Monoclonal antibody
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 1 [532531]
Company
AgonOx
Target and Pathway
Target(s) Tumor necrosis factor receptor superfamily member 4 Target Info Modulator [543513]
KEGG Pathway Cytokine-cytokine receptor interaction
NetPath Pathway IL2 Signaling Pathway
Wnt Signaling Pathway
Pathway Interaction Database Downstream signaling in na&#xef
Reactome TNFs bind their physiological receptors
References
Ref 532531OX40 is a potent immune-stimulating target in late-stage cancer patients. Cancer Res. 2013 Dec 15;73(24):7189-98.
Ref 543513(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1873).

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