Drug Information

Drug General Information
Drug ID
D0YK7C
Former ID
DNC003628
Drug Name
XR-5118
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Terminated [546207]
Structure
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2D MOL

3D MOL
Formula
C20H21N3O2S2
Canonical SMILES
CN(C)CCSC1=CC=C(S1)C=C2C(=O)NC(=CC3=CC=CC=C3)C(=O)N2
InChI
1S/C20H21N3O2S2/c1-23(2)10-11-26-18-9-8-15(27-18)13-17-20(25)21-16(19(24)22-17)12-14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3,(H,21,25)(H,22,24)/b16-12-,17-13-
InChIKey
ODQGWMYUSNRXFW-MCOFMCJXSA-N
PubChem Compound ID
9932718
Target and Pathway
Target(s) Plasminogen activator inhibitor-1 Target Info Inhibitor [527117]
KEGG Pathway HIF-1 signaling pathway
p53 signaling pathway
Hippo signaling pathway
Complement and coagulation cascades
Chagas disease (American trypanosomiasis)
NetPath Pathway TWEAK Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Blood coagulation
Plasminogen activating cascade
p53 pathway
CCKR signaling map ST
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
p73 transcription factor network
E2F transcription factor network
HIF-2-alpha transcription factor network
Direct p53 effectors
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
HIF-1-alpha transcription factor network
Reactome Platelet degranulation
BMAL1:CLOCK,NPAS2 activates circadian gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
ECM proteoglycans
Dissolution of Fibrin Clot
WikiPathways Senescence and Autophagy in Cancer
TGF Beta Signaling Pathway
Complement and Coagulation Cascades
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Blood Clotting Cascade
Extracellular matrix organization
Oncostatin M Signaling Pathway
Adipogenesis
Dissolution of Fibrin Clot
Circadian Clock
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 546207Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006898)
Ref 527117J Med Chem. 2004 Jul 1;47(14):3491-4.Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization.

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