Drug Information

Drug General Information
Drug ID
D0Z5AV
Former ID
DNCL003519
Drug Name
E5501
Drug Type
Small molecular drug
Indication Idiopathic thrombocytopenic purpura [ICD9: 287.31; ICD10:D69.3] Phase 3 [523622]
Company
Eisai
Structure
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2D MOL

3D MOL
Formula
C33H38Cl2N6O7S2
Canonical SMILES
C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5C<br />CC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl.C(=CC(=O)O)C(=O)O
InChI
1S/C29H34Cl2N6O3S2.C4H4O4/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40;5-3(6)1-2-4(7)8/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
MISPBGHDNZYFNM-BTJKTKAUSA-N
PubChem Compound ID
9918581
PubChem Substance ID
14889047, 24196785, 45990222, 78363911, 136349980, 160692703, 162108666, 163312338, 198978504
Target and Pathway
Target(s) Thrombopoietin Receptor Target Info Agonist [543468]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways Platelet Aggregation (Plug Formation)
References
Ref 523622ClinicalTrials.gov (NCT01433978) A Phase 3, Multicenter, Randomized, Double-blind, Active-controlled, Parallel-group Trial With an Open-label Extension Phase to Evaluate the Efficacy and Safety of Oral E5501 Versus Eltrombopag, in Adults With Chronic Immune Thrombocytopenia (Idiopathic Thrombocytopenic Purpura). U.S. National Institutes of Health.
Ref 543468(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).

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