Drug Information

Drug General Information
Drug ID
D0Z9NY
Former ID
DIB016803
Drug Name
API-023
Synonyms
AGN-201904; Proton pump inhibitor prodrug, Alevium; Proton pump inhibitor prodrug, Allergan; AGN-201904-Z; Omeprazole prodrug (GERD), Alevium
Indication Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10:K21] Phase 1 [521830]
Company
Allergan Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(nc2c(n1S(=O)(=O)c1ccc(cc1)OCC(=O)[O-])ccc(c2)OC)S(=O<br />)Cc1c(c(c(cn1)C)OC)C.[Na+]
CAS Number
CAS 651728-41-5
Target and Pathway
Target(s) Potassium-transporting ATPase alpha chain 1 Target Info Inhibitor [543965]
KEGG Pathway Oxidative phosphorylation
Collecting duct acid secretion
Gastric acid secretion
PathWhiz Pathway Gastric Acid Production
Reactome Ion transport by P-type ATPases
WikiPathways Iron uptake and transport
Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 521830ClinicalTrials.gov (NCT00325715) AGN 201904 Versus Esomeprazole in the Prevention of Aspirin-induced Stomach or Upper Intestinal Damage in Healthy Volunteers. U.S. National Institutes of Health.
Ref 543965(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849).

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