Resistance mutation info of target

Target General Information
Target ID T96760
Target Name Growth differentiation factor-5 (GDF5) Target Info
Gene Name GDF5
Species Homo sapiens
Uniprot ID GDF5_HUMAN
Sequence MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRP
GGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATAR
TVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTL
SDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELR
ILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLF
RNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKA
RSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIA
PLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFID
SANNVVYKQYEDMVVESCGCR [Homo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Ref 1572605The ChEMBL database in 2017.
Mutation Info Missense: N445K
Drugs
Drug Name NOGGIN Drug Info [1559260]
Targeted Disease Multiple synostosis syndrome
Mutation Info Missense: N445T
Drugs
Drug Name NOGGIN Drug Info [1559260]
Targeted Disease Multiple synostosis syndrome
Reference
Ref 1559260Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.PLoS Genet.2009 Nov;5(11):e1000747.

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