Target Information

Target General Infomation
Target ID
T46084
Former ID
TTDI02193
Target Name
TNF related apoptosis inducing ligand
Gene Name
TNFSF10
Synonyms
Apo-2 ligand; Apo-2L; CD253; Protein TRAIL; Tumor necrosis factor ligand superfamily member 10; TNFSF10
Target Type
Clinical Trial
Disease Brain cancer [ICD9: 191, 225.0; ICD10: C71, D33]
Indolent relapsed non-hodgkin's lymphoma; Metastatic non-small cell lung cancer; Metastatic colorectal cancer [ICD9:140-229, 162, 200, 202, 202.8, 204.0, 153, 154; ICD10: C33, C33-C34, C34, C81-C86, C82-C85, C91.0, C18-C21]
Prostate cancer [ICD9: 185; ICD10: C61]
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
BioChemical Class
Cytokine: tumor necrosis factor
UniProt ID
P50591
Sequence
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
Drugs and Mode of Action
Drug(s) Ad5-TRAIL Drug Info Phase 1 Prostate cancer [551576]
DA-3607 Drug Info Phase 1 Brain cancer [548564]
Dulanermin Drug Info Terminated Indolent relapsed non-hodgkin's lymphoma; Metastatic non-small cell lung cancer; Metastatic colorectal cancer [550794]
Modulator Ad5-TRAIL Drug Info [528010]
Dulanermin Drug Info [556264]
Binder DA-3607 Drug Info [527776]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
FoxO signaling pathway
Apoptosis
Natural killer cell mediated cytotoxicity
Measles
Influenza A
NetPath Pathway IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Pathway Interaction Database TRAIL signaling pathway
Caspase Cascade in Apoptosis
Reactome Ligand-dependent caspase activation
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling
WikiPathways Apoptosis
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
TP53 Network
References
Ref 548564Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026657)
Ref 550794Clinical pipeline report, company report or official report of Genentech (2011).
Ref 551576Phase I trial of Ad5-TRAIL-mediated gene transfer in men with locally-confined prostate cancer prior to planned radical prostatectomy. The Journal of Urology. 04/2008; 179(4):396-396.
Ref 527776Cancer gene therapy using a novel secretable trimeric TRAIL. Gene Ther. 2006 Feb;13(4):330-8.
Ref 528010Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors. Cancer Gene Ther. 2006 Jun;13(6):628-32.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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