Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T13086
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| Former ID |
TTDNR00709
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| Target Name |
Netrin-1
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| Gene Name |
NTN1
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| Synonyms |
Epididymis tissue protein Li 131P; NTN1
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| Target Type |
Research
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| Function |
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either Dor some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
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| UniProt ID | |||||
| Sequence |
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAF
GKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCW QSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQ CRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQD WVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDD SLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLS GRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTT GQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASK GKLKINMKKYCKKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSR DIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGK CKKA |
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| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | Axon guidance | ||||
| PANTHER Pathway | Axon guidance mediated by Slit/Robo | ||||
| Axon guidance mediated by netrin | |||||
| Pathway Interaction Database | Netrin-mediated signaling events | ||||
| Reactome | DSCAM interactions | ||||
| DCC mediated attractive signaling | |||||
| Netrin mediated repulsion signals | |||||
| Role of second messengers in netrin-1 signaling | |||||
| WikiPathways | Spinal Cord Injury | ||||
| Netrin-1 signaling | |||||
| DSCAM interactions | |||||
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