Target Information

Target General Infomation
Target ID
T27297
Former ID
TTDR00470
Target Name
Proto-oncogene C-crk
Gene Name
CRK
Synonyms
Adapter molecule crk; P38; CRK
Target Type
Research
Function
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
BioChemical Class
Transmembrane protein
UniProt ID
P46108
Sequence
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
EDFS
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
Focal adhesion
Fc gamma R-mediated phagocytosis
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
Bacterial invasion of epithelial cells
Shigellosis
Pathways in cancer
MicroRNAs in cancer
Renal cell carcinoma
Chronic myeloid leukemia
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiogenesis
Integrin signalling pathway
CCKR signaling map ST
Pathway Interaction Database Endothelins
LPA receptor mediated events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Nectin adhesion pathway
Signaling events regulated by Ret tyrosine kinase
Angiopoietin receptor Tie2-mediated signaling
CXCR4-mediated signaling events
IGF1 pathway
E-cadherin signaling in the nascent adherens junction
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
EPHA forward signaling
PDGFR-beta signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
JNK signaling in the CD4+ TCR pathway
PDGFR-alpha signaling pathway
VEGFR3 signaling in lymphatic endothelium
Alpha4 beta1 integrin signaling events
RAC1 signaling pathway
Signaling events mediated by focal adhesion kinase
Reactome ARMS-mediated activation
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
Regulation of signaling by CBL
WikiPathways TCR Signaling Pathway
ErbB Signaling Pathway
Interferon type I signaling pathways
Regulation of Actin Cytoskeleton
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Focal Adhesion
Kit receptor signaling pathway
Fcgamma receptor (FCGR) dependent phagocytosis
Integrated Pancreatic Cancer Pathway
B Cell Receptor Signaling Pathway
Prostate Cancer
Signaling by PDGF
Signaling by Insulin receptor
NGF signalling via TRKA from the plasma membrane
Integrin-mediated Cell Adhesion
Interleukin-3, 5 and GM-CSF signaling
Integrin alphaIIb beta3 signaling

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