Target Information

Target General Infomation
Target ID
T02562
Former ID
TTDR00630
Target Name
Prostaglandin E synthase
Gene Name
PTGES
Synonyms
MGST1-L1; MPGES-1; Microsomal glutathione S-transferase 1-like 1; Microsomal prostaglandin E synthase 1; P53-induced apoptosis protein 12; PGE synthase; PTGES
Target Type
Clinical Trial
Disease Alzheimer disease [ICD9: 331; ICD10: G30]
Function
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
BioChemical Class
Intramolecular oxidoreductases
Target Validation
T02562
UniProt ID
O14684
EC Number
EC 5.3.99.3
Sequence
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
Drugs and Mode of Action
Drug(s) AAD-2004 Drug Info Phase 1 Alzheimer disease [531887]
L-655240 Drug Info Terminated Discovery agent [544543]
Inhibitor AAD-2004 Drug Info [531887]
L-655240 Drug Info [527593]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TCR Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid Synthesis
References
Ref 531887Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.
Ref 544543Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000094)
Ref 527593Bioorg Med Chem Lett. 2005 Jul 15;15(14):3352-5.Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
Ref 531887Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.

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