Target Information
Target General Infomation | |||||
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Target ID |
T60514
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Former ID |
TTDI02085
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Target Name |
Platelet glycoprotein VI
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Gene Name |
GP6
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Synonyms |
GPVI; Glycoprotein 6; GP6
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Target Type |
Clinical Trial
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Disease | Arteriosclerosis [ICD9: 440; ICD10: I70] | ||||
Function |
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
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UniProt ID | |||||
Sequence |
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLE
KLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQP GPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRC YSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFT TETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRH RGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | ECM-receptor interaction | ||||
Platelet activation | |||||
Reactome | GPVI-mediated activation cascade | ||||
Cell surface interactions at the vascular wall | |||||
Platelet Adhesion to exposed collagen | |||||
WikiPathways | Platelet Adhesion to exposed collagen | ||||
GPVI-mediated activation cascade | |||||
Cell surface interactions at the vascular wall | |||||
References |
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