Target Information

Target General Infomation
Target ID
T28717
Former ID
TTDI02196
Target Name
TNF superfamily receptor 12A
Gene Name
TNFRSF12A
Synonyms
CD266; FGF-inducible 14; Fibroblast growth factor-inducible immediate-early response protein 14; Tumor necrosis factor receptor superfamily member 12A; Tweak-receptor; TweakR; TNFRSF12A
Target Type
Clinical Trial
Disease Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Function
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
BioChemical Class
Cytokine receptor
UniProt ID
Q9NP84
Sequence
MARGSLRRLLRLLVLGLWLALLRSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPH
SDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWRRCRRREKFTTPIEETGGE
GCPAVALIQ
Drugs and Mode of Action
Drug(s) Enavatuzumab Drug Info Phase 1 Solid tumours [532085]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
WikiPathways TWEAK Signaling Pathway
References
Ref 532085Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb. J Cancer Res Clin Oncol. 2013 Feb;139(2):315-25.
Ref 532085Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb. J Cancer Res Clin Oncol. 2013 Feb;139(2):315-25.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.