Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06SBB
|
||||
| Former ID |
DAP000388
|
||||
| Drug Name |
Basiliximab
|
||||
| Synonyms |
Simulect (TN)
|
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| Drug Type |
Monoclonal antibody
|
||||
| Therapeutic Class |
Immunomodulatory Agents
|
||||
| Company |
Norvatis Phamaceuticals Corporation
|
||||
| Formula |
C6378H9844N1698O1997S48
|
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| CAS Number |
CAS 152923-56-3
|
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| SuperDrug ATC ID |
L04AC02
|
||||
| Target and Pathway | |||||
| Target(s) | Interleukin-2 receptor alpha chain | Target Info | Modulator | [556264] | |
| PANTHER Pathway | Interleukin signaling pathway | ||||
| Pathway Interaction Database | IL12-mediated signaling events | ||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||||
| Arf6 trafficking events | |||||
| SHP2 signaling | |||||
| IL2-mediated signaling events | |||||
| IL2 signaling events mediated by PI3K | |||||
| IL2 signaling events mediated by STAT5 | |||||
| Calcium signaling in the CD4+ TCR pathway | |||||
| Downstream signaling in naï | |||||
| IL12 signaling mediated by STAT4 | |||||
| References | |||||
| Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
| Ref 541935 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6879). | ||||
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