Drug Information

Drug General Information
Drug ID
D01KKE
Former ID
DCL000834
Drug Name
GW876008
Synonyms
GW-876008
Drug Type
Small molecular drug
Indication Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] Discontinued in Phase 2 [536580]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C22H24N6O2
Canonical SMILES
CC1=C(C=CC(=C1)OC)N2CCC3=C2N=C(C=C3N4C=CC(=N4)N5CCNC5=O<br />)C
InChI
1S/C22H24N6O2/c1-14-12-16(30-3)4-5-18(14)26-9-6-17-19(13-15(2)24-21(17)26)28-10-7-20(25-28)27-11-8-23-22(27)29/h4-5,7,10,12-13H,6,8-9,11H2,1-3H3,(H,23,29)
InChIKey
JFHJGXQFESYQGY-UHFFFAOYSA-N
PubChem Compound ID
11223423
PubChem Substance ID
16306697, 23405868, 42303037, 76678986, 103647413, 124490350, 135330024, 163361822, 163679274, 198940010, 224068229, 228320679, 243028533
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Antagonist [536580]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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