Drug Information

Drug General Information
Drug ID
D0V8GX
Former ID
DIB018934
Drug Name
AZD8542
Synonyms
AZD 8542; AZD-8542
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531989]
Structure
Download
2D MOL
Formula
C25H24N4O2
InChI
InChI=1S/C25H24N4O2/c1-17-12-18(2)23(13-22(17)24-14-29(3)16-27-24)28-25(30)19-7-9-21(10-8-19)31-15-20-6-4-5-11-26-20/h4-14,16H,15H2,1-3H3,(H,28,30)
InChIKey
SMQVBAGSZVHCJP-UHFFFAOYSA-N
PubChem Compound ID
53344810
PubChem Substance ID
125009717, 223366049, 228470018
Target and Pathway
Target(s) smoothened receptor Target Info Antagonist [543616]
KEGG Pathway Hedgehog signaling pathway
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
PANTHER Pathway Hedgehog signaling pathway
Pathway Interaction Database Signaling events mediated by the Hedgehog family
Hedgehog signaling events mediated by Gli proteins
Reactome Class B/2 (Secretin family receptors)
Hedgehog 'off' state
Activation of SMO
WikiPathways Hedgehog Signaling Pathway
Hair Follicle Development: Organogenesis (Part 2 of 3)
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
GPCR ligand binding
GPCRs, Other
References
Ref 531989Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. Mol Cancer Res. 2012 Sep;10(9):1147-57. Epub 2012 Aug 2.
Ref 543616(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 239).

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