Drug Information

Drug General Information
Drug ID
D04KWH
Former ID
DNC000535
Drug Name
Des-Arg(9)-[Leu(8)]-BK
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535320]
Structure
Download
2D MOL

3D MOL
Formula
C18H20Cl4N4
Canonical SMILES
CCCN(CC1CC1)C2=NC(=NC(=C2Cl)NC3=C(C=C(C=C3Cl)Cl)Cl)C
InChI
1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
InChIKey
KNADXBVKFAUMCR-UHFFFAOYSA-N
CAS Number
CAS 184241-44-9
PubChem Compound ID
176157
PubChem Substance ID
5916225, 7980096, 10258352, 11111536, 11114145, 14930153, 17405056, 24278425, 33499833, 46500411, 47276706, 50069830, 50104903, 50104904, 53777599, 53788663, 53801052, 57395288, 80947329, 85231154, 85788155, 90340601, 92304048, 103225612, 103950895, 104425366, 121361191, 124749758, 124799473, 124880882, 124880883, 134339939, 134340268, 135154099, 135298261, 162248258, 163564447, 178126277, 179235782
Target and Pathway
Target(s) B1 bradykinin receptor Target Info Antagonist [535320]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways Complement and Coagulation Cascades
ACE Inhibitor Pathway
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 535320Evidence for the participation of kinins in Freund's adjuvant-induced inflammatory and nociceptive responses in kinin B1 and B2 receptor knockout mice. Neuropharmacology. 2001 Dec;41(8):1006-12.
Ref 535320Evidence for the participation of kinins in Freund's adjuvant-induced inflammatory and nociceptive responses in kinin B1 and B2 receptor knockout mice. Neuropharmacology. 2001 Dec;41(8):1006-12.

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