TTD | Drug: D0J2VQ

Drug General Information
Drug ID	D0J2VQ
Former ID	DIB019812
Drug Name	EM-523
Synonyms	N-ethyl,N-methyl EM-A enolether; erythromycin analogue (523)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538921]
Structure		Download 2D MOL
Formula	C38H67NO12
InChI	InChI=1S/C38H67NO12/c1-14-26-38(11,44)31(41)21(5)29-19(3)17-37(10,51-29)33(50-35-28(40)25(39(12)15-2)16-20(4)46-35)22(6)30(23(7)34(43)48-26)49-27-18-36(9,45-13)32(42)24(8)47-27/h20-28,30-33,35,40-42,44H,14-18H2,1-13H3/t20-,21+,22+,23-,24+,25+,26-,27+,28-,30+,31-,32+,33-,35+,36-,37+,38-/m1/s1
InChIKey	UTTLXGDLSXWDJI-OTELOYJSSA-N
PubChem Compound ID	184178
PubChem Substance ID	79855476, 104441467, 135163100, 135652681
Target and Pathway
Target(s)	Motilin receptor	Target Info	Agonist	[527468]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538921	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1445).
Ref 527468	Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. Epub 2005 Mar 11.

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Drug Information