Drug Information

Drug General Information
Drug ID
D0J0TP
Former ID
DNC007752
Drug Name
DIRLOTAPIDE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528651]
Structure
Download
2D MOL

3D MOL
Formula
C40H33F3N4O3
Canonical SMILES
CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F<br />)C=C1C(=O)NC(C5=CC=CC=C5)C(=O)N(C)CC6=CC=CC=C6
InChI
1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1
InChIKey
TUOSYWCFRFNJBS-BHVANESWSA-N
CAS Number
CAS 481658-94-0
PubChem Compound ID
9917862
Target and Pathway
Target(s) Microsomal triglyceride transfer protein, large subunit Target Info Inhibitor [528651]
KEGG Pathway Fat digestion and absorption
Reactome Chylomicron-mediated lipid transport
WikiPathways Statin Pathway
Lipid digestion, mobilization, and transport
References
Ref 528651Bioorg Med Chem Lett. 2007 Apr 1;17(7):1996-9. Epub 2007 Jan 17.In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity.
Ref 528651Bioorg Med Chem Lett. 2007 Apr 1;17(7):1996-9. Epub 2007 Jan 17.In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity.

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