Drug Information

Drug General Information
Drug ID
D06KMO
Former ID
DNC000352
Drug Name
Brocresine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [536583], [537766]
Structure
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2D MOL

3D MOL
Formula
C7H8BrNO2
Canonical SMILES
C1=CC(=C(C=C1CON)O)Br
InChI
1S/C7H8BrNO2/c8-6-2-1-5(4-11-9)3-7(6)10/h1-3,10H,4,9H2
InChIKey
QNWOSJAGFSUDFE-UHFFFAOYSA-N
CAS Number
CAS 42228-92-2
PubChem Compound ID
11151
PubChem Substance ID
8158133, 15244914, 17397312, 29279481, 49956379, 57326727, 76213198, 104325270, 129050035, 134339798, 134976703, 137048471, 140121323, 160687278, 179225547, 198979258, 223844573, 226935290, 242080897, 250064325, 252450945
Target and Pathway
Target(s) Histidine decarboxylase Target Info Inhibitor [536583], [537766]
KEGG Pathway Histidine metabolism
Metabolic pathways
PANTHER Pathway Histamine synthesis
CCKR signaling map ST
PathWhiz Pathway Histidine Metabolism
WikiPathways Biogenic Amine Synthesis
Metabolism of amino acids and derivatives
References
Ref 536583Histamine in brain--its role in regulation of seizure susceptibility. Epilepsy Res. 1991 Nov-Dec;10(2-3):111-8.
Ref 537766Effects of brocresine (NSD-1055) and cycloheximide on amino acid decarboxylase activities in gastric mucosa of normal and vagally denervated rats. Br J Pharmacol. 1972 Dec;46(4):688-95.
Ref 536583Histamine in brain--its role in regulation of seizure susceptibility. Epilepsy Res. 1991 Nov-Dec;10(2-3):111-8.
Ref 537766Effects of brocresine (NSD-1055) and cycloheximide on amino acid decarboxylase activities in gastric mucosa of normal and vagally denervated rats. Br J Pharmacol. 1972 Dec;46(4):688-95.

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