Drug Information

Drug General Information
Drug ID
D0ZE9M
Former ID
DNC006580
Drug Name
N-(4-tert-butylthiazol-2-yl)isoquinolin-5-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528047]
Structure
Download
2D MOL

3D MOL
Formula
C16H17N3S
Canonical SMILES
CC(C)(C)C1=CSC(=N1)NC2=CC=CC3=C2C=CN=C3
InChI
1S/C16H17N3S/c1-16(2,3)14-10-20-15(19-14)18-13-6-4-5-11-9-17-8-7-12(11)13/h4-10H,1-3H3,(H,18,19)
InChIKey
JVTUKUHMGYMFFT-UHFFFAOYSA-N
PubChem Compound ID
44411492
Target and Pathway
Target(s) C-Cchemokine receptor type 4 Target Info Inhibitor [528047]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528047Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.
Ref 528047Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.