Drug Information

Drug General Information
Drug ID
D0E5QN
Former ID
DIB019115
Drug Name
CGP 71872
Synonyms
CGP71872; CGP-71872
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538657]
Structure
Download
2D MOL
Formula
C24H31IN5O7P
InChI
InChI=1S/C24H31IN5O7P/c1-15(16-6-5-7-17(10-16)24(34)35)28-13-18(31)14-38(36,37)9-4-2-3-8-27-23(33)19-11-20(25)21(29-30-26)12-22(19)32/h5-7,10-12,15,18,28,31-32H,2-4,8-9,13-14H2,1H3,(H,27,33)(H,34,35)(H,36,37)/t15-,18+/m1/s1
InChIKey
IHFUJPDKHJTHGQ-QAPCUYQASA-N
PubChem Compound ID
6324595
PubChem Substance ID
7978469, 11600124, 15063565, 42973581, 53698549, 57365633, 114481987, 135650079, 135727662, 242502142
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Antagonist [534343]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 538657(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1074).
Ref 534343Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46.

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