Drug Information

Drug General Information
Drug ID
D0UH9E
Former ID
DIB019631
Drug Name
compound B
Synonyms
Cpd-B; cpd B
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529472], [540321]
Structure
Download
2D MOL
Formula
C17H12ClF3N2O3S
InChI
InChI=1S/C17H12ClF3N2O3S/c1-8-4-11(3-2-9(8)5-13-14(24)23-16(25)27-13)26-15-12(18)6-10(7-22-15)17(19,20)21/h2-4,6-7,13H,5H2,1H3,(H,23,24,25)
InChIKey
ZAMASFSDWVSMSY-UHFFFAOYSA-N
PubChem Compound ID
46216676
PubChem Substance ID
96071033, 103727219, 178100391, 252214493
Target and Pathway
Target(s) GPR40 Target Info Agonist [529472]
KEGG Pathway Insulin secretion
Reactome G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways GPCRs, Class A Rhodopsin-like
Incretin Synthesis, Secretion, and Inactivation
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 529472Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes. 2008 Aug;57(8):2211-9.
Ref 540321(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3367).
Ref 529472Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes. 2008 Aug;57(8):2211-9.

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