Drug Information

Drug General Information
Drug ID
D01PWM
Former ID
DIB020149
Drug Name
kuwanon H
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541389]
Structure
Download
2D MOL
Formula
C45H44O11
InChI
InChI=1S/C45H44O11/c1-21(2)6-10-27-33(48)15-14-29(41(27)53)42(54)38-31(26-12-8-24(46)18-34(26)49)16-23(5)17-32(38)39-36(51)20-37(52)40-43(55)30(11-7-22(3)4)44(56-45(39)40)28-13-9-25(47)19-35(28)50/h6-9,12-15,17-20,31-32,38,46-53H,10-11,16H2,1-5H3/t31-,32-,38-/m0/s1
InChIKey
DKBPTKFKCCNXNH-QXGWMLRCSA-N
PubChem Compound ID
5281668
PubChem Substance ID
12286, 15039439, 29157099, 39290450, 50198039, 103581621, 113855631, 125317221, 135152149, 135652700, 223440106, 226515802
Target and Pathway
Target(s) Gastrin-releasing peptide receptor Target Info Antagonist [533672]
Bombesin receptor Target Info Antagonist [533672]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 541389(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 622).
Ref 533672Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9.

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