Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0E7NT
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| Former ID |
DNC001475
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| Drug Name |
TrkA-IgG
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [535214] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C63H111N11O12
|
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| Canonical SMILES |
CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C<br />(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC=<br />C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C<br />)C)C)C
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| InChI |
1S/C63H111N11O12/c1-25-27-28-29-41(15)53(76)52-57(80)66-44(26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27-28,35-48,50-53,76H,1,26,29-34H2,2-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b28-27+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/m1/s1
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| InChIKey |
BICRTLVBTLFLRD-PTWUADNWSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Tumor necrosis factor receptor superfamily member 16 | Target Info | Antagonist | [535214] | |
| Pathway Interaction Database | p75(NTR)-mediated signaling | ||||
| Neurotrophic factor-mediated Trk receptor signaling | |||||
| Reactome | Axonal growth inhibition (RHOA activation) | ||||
| NRAGE signals death through JNK | |||||
| p75NTR negatively regulates cell cycle via SC1 | |||||
| Regulated proteolysis of p75NTR | |||||
| NADE modulates death signalling | |||||
| NRIF signals cell death from the nucleus | |||||
| p75NTR recruits signalling complexes | |||||
| NF-kB is activated and signals survival | |||||
| Axonal growth stimulation | |||||
| References | |||||
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