Drug Information

Drug General Information
Drug ID
D0R3CY
Former ID
DNC003825
Drug Name
SB-265123
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527268]
Structure
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2D MOL

3D MOL
Formula
C25H26N2O3
Canonical SMILES
C1C(C2=CC=CC=C2CC3=C1C=CC(=C3)OCCCNC4=CC=CC=N4)CC(=O)O
InChI
1S/C25H26N2O3/c28-25(29)17-21-14-18-9-10-22(16-20(18)15-19-6-1-2-7-23(19)21)30-13-5-12-27-24-8-3-4-11-26-24/h1-4,6-11,16,21H,5,12-15,17H2,(H,26,27)(H,28,29)/t21-/m0/s1
InChIKey
HODBWQCCKYDYPY-NRFANRHFSA-N
PubChem Compound ID
9952958
Target and Pathway
Target(s) Integrin alpha-V Target Info Inhibitor [527268]
Integrin beta-1 Target Info Inhibitor [525536]
mRNA of integrin beta 3 Target Info Inhibitor [527268]
KEGG Pathway Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathyhsa04015:Rap1 signaling pathway
Axon guidance
Platelet activation
Leukocyte transendothelial migration
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Pertussis
Leishmaniasis
Toxoplasmosis
Osteoclast differentiation
Hematopoietic cell lineage
MicroRNAs in cancer
Dilated cardiomyopathy
NetPath Pathway Leptin Signaling Pathway
PANTHER Pathway Integrin signalling pathway
CCKR signaling map STP00031:Inflammation mediated by chemokine and cytokine signaling pathway
CCKR signaling map ST
Pathway Interaction Database Beta1 integrin cell surface interactions
Integrin family cell surface interactions
Beta3 integrin cell surface interactions
S1P3 pathway
Osteopontin-mediated events
Arf6 trafficking events
Nectin adhesion pathway
S1P1 pathway
CXCR4-mediated signaling events
Plexin-D1 Signaling
Integrins in angiogenesis
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
PDGFR-alpha signaling pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events mediated by focal adhesion kinaseprlsignalingeventspathway:Signaling events mediated by PRL
RhoA signaling pathway
Reelin signaling pathway
Signaling events mediated by TCPTP
Angiopoietin receptor Tie2-mediated signaling
Alpha9 beta1 integrin signaling events
Syndecan-4-mediated signaling events
a4b7 Integrin signaling
a6b1 and a6b4 Integrin signaling
Syndecan-2-mediated signaling events
Validated targets of C-MYC transcriptional repression
VEGFR3 signaling in lymphatic endothelium
Alpha4 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinaseil4_2pathway:IL4-mediated signaling events
Signaling events mediated by PTP1B
Arf6 signaling events
Ephrin B reverse signaling
Reactome Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
VEGFA-VEGFR2 PathwayR-HSA-1566948:Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Other semaphorin interactions
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
CHL1 interactions
RHO GTPases Activate Formins
Platelet Adhesion to exposed collagenR-HSA-114608:Platelet degranulation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
MAP2K and MAPK activation
WikiPathways Osteoblast Signaling
Focal Adhesion
Class I MHC mediated antigen processing & presentation
Syndecan interactions
Extracellular matrix organization
Elastic fibre formation
Primary Focal Segmental Glomerulosclerosis FSGS
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
Cell surface interactions at the vascular wall
Osteopontin SignalingWP366:TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Hair Follicle Development: Organogenesis (Part 2 of 3)
Nanoparticle-mediated activation of receptor signaling
JAK/STAT
Pathogenic Escherichia coli infection
Neural Crest Differentiation
Semaphorin interactions
Platelet Adhesion to exposed collagen
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell junction organizationWP727:Monoamine Transport
TGF beta Signaling Pathway
Hematopoietic Stem Cell Differentiation
Human Complement System
Integrin alphaIIb beta3 signaling
Serotonin Transporter Activity
Osteopontin Signaling
Osteoclast Signaling
References
Ref 527268Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41.1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability.
Ref 525536Bioorg Med Chem Lett. 1999 Jul 5;9(13):1807-12.Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.
Ref 527268Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41.1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability.

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