Drug Information

Drug General Information
Drug ID
D0K1XK
Former ID
DAP000728
Drug Name
Hydralazine
Synonyms
Apresolin; Apresoline; Apressin; Apressoline; Aprezolin; HLZ; Hidral; Hidralazin; Hidralazina; Hipoftalin; Hydralazin; Hydralazinum; Hydrallazin; Hydrallazine; Hydrazinophthalazine; Hypophthalin; Idralazina; Hidralazina [Spanish]; Idralazina [DCIT]; Idralazina [Italian]; BA 5968; C 5968; Ciba 5968; Praparat 5968; Apresoline (TN); Apressin (pharmaceutical); C-5068; C-5968; Hidral (TN); Hidralazina [INN-Spanish]; Hydralazine (INN); Hydralazine [INN:BAN]; Hydralazinum [INN-Latin]; Hydrazone 1(2H)-phthalazinone; Phthalazin-1-ylhydrazine; [2H-Phthalazin-(1Z)-Ylidene]-Hydrazine Hydrochloride; (1Z)-1(2H)-Phthalazinone hydrazone; (2H)-Phthalazinone hydrazone; 1(2H)-Phthalazinone hydrazone; 1(2H)-Phthalazinone, hydrazone; 1-Hydrazinophthalazine; 1-Phthalazinylhydrazine; 6-Hydralazine
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [542349], [550666]
Therapeutic Class
Antihypertensive Agents
Structure
Download
2D MOL

3D MOL
Formula
C8H8N4
InChI
InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
InChIKey
RPTUSVTUFVMDQK-UHFFFAOYSA-N
CAS Number
CAS 86-54-4
PubChem Compound ID
3637
PubChem Substance ID
9252, 418631, 5137562, 6166136, 7979543, 8152294, 10537093, 11111261, 11111262, 11335292, 11360531, 11363769, 11366331, 11368893, 11371450, 11373488, 11377055, 11449000, 11461503, 11466197, 11467317, 11484713, 11485694, 11488785, 11490271, 11491820, 11494689, 15171016, 29203528, 29222762, 46507533, 47216638, 47290993, 47440105, 47478169, 47515168, 47662118, 48184848, 48416088, 50010164, 50111090, 53790673, 56313050, 56313323, 56313748, 57321912, 74312335, 77248068, 85789545, 87692111
SuperDrug ATC ID
C02DB02
SuperDrug CAS ID
cas=000086544
Target and Pathway
Target(s) Membrane copper amine oxidase Target Info Modulator [556264]
BioCyc Pathway Phenylethylamine degradation I
Spermine and spermidine degradation I
KEGG Pathway Glycine, serine and threonine metabolism
Tyrosine metabolism
Phenylalanine metabolism
beta-Alanine metabolism
Metabolic pathways
PANTHER Pathway Phenylethylamine degradation
PathWhiz Pathway Beta-Alanine Metabolism
References
Ref 542349(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7326).
Ref 550666Drug information of Hydralazine, 2008. eduDrugs.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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