Drug Information

Drug General Information
Drug ID
D0I9JH
Former ID
DNC014756
Drug Name
L-655240
Drug Type
Small molecular drug
Indication Discovery agent Terminated [544543]
Structure
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2D MOL

3D MOL
Formula
C21H21ClFNO2
Canonical SMILES
CC1=C(N(C2=C1C=C(C=C2)F)CC3=CC=C(C=C3)Cl)CC(C)(C)C(=O)O
InChI
1S/C21H21ClFNO2/c1-13-17-10-16(23)8-9-18(17)24(12-14-4-6-15(22)7-5-14)19(13)11-21(2,3)20(25)26/h4-10H,11-12H2,1-3H3,(H,25,26)
InChIKey
JLPYLHLUHJOPNL-UHFFFAOYSA-N
PubChem Compound ID
122070
Target and Pathway
Target(s) Prostaglandin E synthase Target Info Inhibitor [527593]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TCR Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid Synthesis
References
Ref 544543Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000094)
Ref 527593Bioorg Med Chem Lett. 2005 Jul 15;15(14):3352-5.Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.

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