TTD | Drug: D01CCG

Drug General Information
Drug ID	D01CCG
Former ID	DIB021094
Drug Name	TUG-424
Synonyms	TUG424
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540574]
Structure		Download 2D MOL
Formula	C18H16O2
InChI	InChI=1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
InChIKey	FODHWOBAQBTTFS-UHFFFAOYSA-N
PubChem Compound ID	25150014
PubChem Substance ID	56482242, 85006353, 103648704, 104119019, 123220363, 125333642, 138561714, 162248516, 163125685, 172919791, 178100779, 204357023, 227749309, 241376637, 247703081, 252157538, 252216535, 252457234
Target and Pathway
Target(s)	GPR40	Target Info	Agonist	[529762]
KEGG Pathway	Insulin secretion
Reactome	G alpha (q) signalling events
Reactome	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways	GPCRs, Class A Rhodopsin-like
	Incretin Synthesis, Secretion, and Inactivation
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540574	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3952).
Ref 529762	Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes. J Med Chem. 2008 Nov 27;51(22):7061-4.

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Drug Information