Drug Information

Drug General Information
Drug ID
D0N7VL
Former ID
DNC011291
Drug Name
Asp-BrPmp-Leu
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531253]
Structure
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2D MOL

3D MOL
Formula
C20H29BrN3O9P
Canonical SMILES
CC(C)CC(C(=O)O)NC(=O)C(CC1=CC=C(C=C1)C(P(=O)(O)O)Br)NC(<br />=O)C(CC(=O)O)N
InChI
1S/C20H29BrN3O9P/c1-10(2)7-15(20(29)30)24-19(28)14(23-18(27)13(22)9-16(25)26)8-11-3-5-12(6-4-11)17(21)34(31,32)33/h3-6,10,13-15,17H,7-9,22H2,1-2H3,(H,23,27)(H,24,28)(H,25,26)(H,29,30)(H2,31,32,33)/t13-,14-,15-,17?/m0/s1
InChIKey
VZSILTSENHCLNI-CKSGOKGCSA-N
PubChem Compound ID
52949968
Target and Pathway
Target(s) Leukocyte common antigen Target Info Inhibitor [531253]
KEGG Pathway Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Primary immunodeficiency
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway B cell activation
JAK/STAT signaling pathway
T cell activation
Pathway Interaction Database BCR signaling pathway
TCR signaling in na&#xef
TCR signaling in na&#xef
CXCR4-mediated signaling events
Reactome Phosphorylation of CD3 and TCR zeta chains
Other semaphorin interactions
WikiPathways Interferon type I signaling pathways
EPO Receptor Signaling
B Cell Receptor Signaling Pathway
TCR signaling
Semaphorin interactions
References
Ref 531253Bioorg Med Chem. 2010 Dec 15;18(24):8679-86. Epub 2010 Sep 29.A protected l-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphataseinhibitors.
Ref 531253Bioorg Med Chem. 2010 Dec 15;18(24):8679-86. Epub 2010 Sep 29.A protected l-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphataseinhibitors.

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