Drug General Information
Drug ID	D0N5ZS
Former ID	DCL000662
Drug Name	Vedolizmab
Drug Type	Monoclonal antibody
Indication	Ulcerative colitis; Crohn's disease [ICD9: 555, 556, 556.9; ICD10:K50, K50-K52, K51]		Approved	[551871]
Company	Millennium Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C25H30N2O8
PubChem Compound ID	24796742
Target and Pathway
Target(s)	Integrin beta-7	Target Info	Antagonist	[551717]
	Integrin alpha-4	Target Info	Antagonist	[551717]
KEGG Pathway	PI3K-Akt signaling pathway
	Focal adhesion
	ECM-receptor interaction
	Cell adhesion molecules (CAMs)
	Intestinal immune network for IgA production
	Regulation of actin cytoskeleton
	Transcriptional misregulation in cancer
	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
	Dilated cardiomyopathyhsa04151:PI3K-Akt signaling pathway
	Hematopoietic cell lineage
	Leukocyte transendothelial migration
	Leishmaniasis
	Dilated cardiomyopathy
NetPath Pathway	IL2 Signaling Pathway
	Wnt Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Integrin signalling pathwayP00034:Integrin signalling pathway
Pathway Interaction Database	Integrin family cell surface interactions
	AlphaE beta7 integrin cell surface interactions
	E-cadherin signaling in the nascent adherens junction
	a4b7 Integrin signaling
	Beta5 beta6 beta7 and beta8 integrin cell surface interactionsintegrin1_pathway:Beta1 integrin cell surface interactions
	Arf6 trafficking events
	CXCR4-mediated signaling events
	Plexin-D1 Signaling
	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
	VEGFR3 signaling in lymphatic endothelium
	Alpha4 beta1 integrin signaling events
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Integrin cell surface interactionsR-HSA-198933:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Cell surface interactions at the vascular wall
	Integrin cell surface interactions
WikiPathways	Focal Adhesion
	Arrhythmogenic Right Ventricular Cardiomyopathy
	Integrin-mediated Cell Adhesion
	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellWP306:Focal Adhesion
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Cell surface interactions at the vascular wall
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 551717	Clinical pipeline report, company report or official report of Takeda (2009).

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