Drug Information

Drug General Information
Drug ID
D0L1OC
Former ID
DCL001146
Drug Name
Anti-LT alpha
Drug Type
Antibody
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 2 [550794]
Company
Genentech
Target and Pathway
Target(s) Lymphotoxin alpha Target Info [550794]
KEGG Pathway Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
TNF signaling pathway
Type I diabetes mellitus
HTLV-I infection
Herpes simplex infection
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Pathway Interaction Database IL4-mediated signaling events
IL2 signaling events mediated by STAT5
Reactome TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
WikiPathways Apoptosis
References
Ref 550794Clinical pipeline report, company report or official report of Genentech (2011).
Ref 550794Clinical pipeline report, company report or official report of Genentech (2011).

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