Drug Information

Drug General Information
Drug ID
D03KJS
Former ID
DNC000213
Drug Name
Antalarmin
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Terminated [540427], [546326]
Structure
Download
2D MOL

3D MOL
Formula
C24H34N4
InChI
InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
InChIKey
IXPROWGEHNVJOY-UHFFFAOYSA-N
CAS Number
CAS 157284-96-3
PubChem Compound ID
177990
PubChem Substance ID
533085, 3249268, 7978712, 10258823, 11444292, 12014909, 14829248, 29217488, 33501322, 50040462, 50815298, 53790815, 57395584, 103224906, 103967718, 104426837, 128235206, 134339708, 135154868, 137006476, 141141924, 178100478, 179294243, 226784410
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Antagonist [534886]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 540427(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3489).
Ref 546326Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007484)
Ref 534886Chronic administration of the non-peptide CRH type 1 receptor antagonist antalarmin does not blunt hypothalamic-pituitary-adrenal axis responses to acute immobilization stress. Life Sci. 1999;65(4):PL53-8.

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