Drug Information

Drug General Information
Drug ID
D0T1OG
Former ID
DNC012161
Drug Name
N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534413]
Structure
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2D MOL

3D MOL
Formula
C10H13N3O3S
Canonical SMILES
CC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N=C(N)N
InChI
1S/C10H13N3O3S/c1-6-3-4-7(17(2,15)16)5-8(6)9(14)13-10(11)12/h3-5H,1-2H3,(H4,11,12,13,14)
InChIKey
SSLQVRLYNHXNIS-UHFFFAOYSA-N
PubChem Compound ID
9992527
Target and Pathway
Target(s) Sodium/hydrogen exchanger 1 Target Info Inhibitor [534413]
Sodium/hydrogen exchanger 3 Target Info Inhibitor [534413]
KEGG Pathway cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Proteoglycans in cancerhsa04964:Proximal tubule bicarbonate reclamation
Protein digestion and absorption
Mineral absorption
Pathway Interaction Database Endothelins
RhoA signaling pathway
ErbB1 downstream signaling
Signaling mediated by p38-alpha and p38-betaendothelinpathway:Endothelins
Reactome Hyaluronan uptake and degradation
WikiPathways Regulation of Actin Cytoskeleton
G Protein Signaling Pathways
Glycosaminoglycan metabolism
Osteoclast SignalingWP706:SIDS Susceptibility Pathways
References
Ref 534413J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Ref 534413J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.

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