Drug Information

Drug General Information
Drug ID
D0W1VL
Former ID
DNC006586
Drug Name
N-(naphthalen-1-yl)-4-phenylthiazol-2-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528047]
Structure
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2D MOL

3D MOL
Formula
C19H14N2S
Canonical SMILES
C1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=CC4=CC=CC=C43
InChI
1S/C19H14N2S/c1-2-8-15(9-3-1)18-13-22-19(21-18)20-17-12-6-10-14-7-4-5-11-16(14)17/h1-13H,(H,20,21)
InChIKey
JWZVJRBKXQFLBH-UHFFFAOYSA-N
PubChem Compound ID
4015979
Target and Pathway
Target(s) C-Cchemokine receptor type 4 Target Info Inhibitor [528047]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528047Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.
Ref 528047Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.

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