Drug General Information
Drug ID	D0H4MB
Former ID	DNC005109
Drug Name	ISONIPECOTAMIDE
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527223]
Structure		Download 2D MOL 3D MOL
Formula	C6H12N2O
Canonical SMILES	C1CNCCC1C(=O)N
InChI	1S/C6H12N2O/c7-6(9)5-1-3-8-4-2-5/h5,8H,1-4H2,(H2,7,9)
InChIKey	DPBWFNDFMCCGGJ-UHFFFAOYSA-N
PubChem Compound ID	3772
Target and Pathway
Target(s)	mRNA of integrin beta 3	Target Info	Inhibitor	[527223]
	Integrin alpha-V	Target Info	Inhibitor	[527223]
KEGG Pathway	Rap1 signaling pathway
	Phagosome
	PI3K-Akt signaling pathway
	Osteoclast differentiation
	Focal adhesion
	ECM-receptor interaction
	Platelet activation
	Hematopoietic cell lineage
	Regulation of actin cytoskeleton
	Thyroid hormone signaling pathway
	Proteoglycans in cancer
	MicroRNAs in cancer
	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
	Dilated cardiomyopathyhsa04145:Phagosome
	Cell adhesion molecules (CAMs)
	Pathways in cancer
	Small cell lung cancer
	Dilated cardiomyopathy
NetPath Pathway	Leptin Signaling Pathway
PANTHER Pathway	Integrin signalling pathway
	CCKR signaling map ST
Pathway Interaction Database	IL4-mediated signaling events
	Integrin family cell surface interactions
	Signaling events mediated by PTP1B
	Beta3 integrin cell surface interactions
	S1P3 pathway
	Osteopontin-mediated events
	Nectin adhesion pathway
	Arf6 signaling events
	S1P1 pathway
	Integrins in angiogenesis
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	PDGFR-beta signaling pathway
	Signaling events mediated by VEGFR1 and VEGFR2
	Ephrin B reverse signalingintegrin1_pathway:Beta1 integrin cell surface interactions
	Arf6 trafficking events
	CXCR4-mediated signaling events
	Plexin-D1 Signaling
	PDGFR-alpha signaling pathway
	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
	Signaling events mediated by focal adhesion kinase
Reactome	Platelet degranulation
	Elastic fibre formation
	PECAM1 interactions
	Molecules associated with elastic fibres
	Integrin cell surface interactions
	Syndecan interactions
	ECM proteoglycans
	Integrin alphaIIb beta3 signaling
	GRB2:SOS provides linkage to MAPK signaling for Integrins
	p130Cas linkage to MAPK signaling for integrins
	VEGFA-VEGFR2 Pathway
	MAP2K and MAPK activationR-HSA-1236973:Cross-presentation of particulate exogenous antigens (phagosomes)
	Laminin interactions
WikiPathways	Monoamine Transport
	TGF beta Signaling Pathway
	Osteoblast Signaling
	Focal Adhesion
	Hematopoietic Stem Cell Differentiation
	Human Complement System
	Syndecan interactions
	Extracellular matrix organization
	Elastic fibre formation
	Primary Focal Segmental Glomerulosclerosis FSGS
	Arrhythmogenic Right Ventricular Cardiomyopathy
	Integrin-mediated Cell Adhesion
	L1CAM interactions
	Integrin cell surface interactions
	Integrin alphaIIb beta3 signaling
	Cell surface interactions at the vascular wall
	Serotonin Transporter Activity
	Osteopontin Signaling
	Osteoclast SignalingWP322:Osteoblast Signaling
	Class I MHC mediated antigen processing & presentation
References
Ref 527223	Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32.Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins.
Ref 527223	Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32.Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins.

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