Drug Information

Drug General Information
Drug ID
D0TD2G
Former ID
DCL000735
Drug Name
Canakinumab
Synonyms
Ilaris (TN)
Drug Type
Antibody
Indication Cryopyrin-associated periodic syndromes; Rheumatoid arthritis [ICD9: 277.31, 322.2, 339.8, 708.2, 708.8, 714.3, 710-719, 714; ICD10:E85.0, G03.1, G44.8, L50.2, L50.8, M08.9, M05-M06] Approved [530677], [541853]
Urticaria; Vasculitis [ICD9: 446, 447.6, 708; ICD10:I77.6, I80, L50, L95, M30-M31] Phase 2 [530677], [541853]
Company
Novartis
CAS Number
CAS 914613-48-2
SuperDrug ATC ID
L04AC08
Target and Pathway
Target(s) Interleukin-1 beta Target Info [530677], [536651]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Hematopoietic cell lineage
TNF signaling pathway
Inflammatory mediator regulation of TRP channels
Non-alcoholic fatty liver disease (NAFLD)
Type I diabetes mellitus
Alzheimer's disease
Prion diseases
Salmonella infection
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex infection
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Graft-versus-host disease
NetPath Pathway Leptin Signaling Pathway
IL5 Signaling Pathway
IL1 Signaling Pathway
IL2 Signaling Pathway
IL3 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Wnt Signaling Pathway
TCR Signaling Pathway
TNFalpha Signaling Pathway
Pathway Interaction Database IL27-mediated signaling events
IL12-mediated signaling events
IL1-mediated signaling events
IFN-gamma pathway
IL23-mediated signaling events
Cellular roles of Anthrax toxin
Reactome Interleukin-1 signaling
Interleukin-1 processing
CLEC7A/inflammasome pathway
WikiPathways Toll-like receptor signaling pathway
Monoamine Transport
SIDS Susceptibility Pathways
TCR Signaling Pathway
Type II interferon signaling (IFNG)
Senescence and Autophagy in Cancer
Cytokines and Inflammatory Response
MAPK Signaling Pathway
Myometrial Relaxation and Contraction Pathways
Aryl Hydrocarbon Receptor Pathway
IL1 and megakaryotyces in obesity
Hematopoietic Stem Cell Differentiation
Spinal Cord Injury
Allograft Rejection
Alzheimers Disease
Leptin signaling pathway
IL-1 signaling pathway
Interleukin-1 signaling
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
Serotonin Transporter Activity
Regulation of toll-like receptor signaling pathway
NOD pathway
References
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 541853(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6773).
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 536651Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.

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