Drug Information

Drug General Information
Drug ID
D05IQX
Former ID
DCL000493
Drug Name
Belimumab
Synonyms
Belimumab (USAN); LymphoStat-B; LymphoStat-B (TN)
Drug Type
Antibody
Indication Systemic lupus erythematosus [ICD9: 710; ICD10:M32] Approved [537129], [541944]
Company
GSK
CAS Number
CAS 356547-88-1
PubChem Substance ID
17397223
SuperDrug ATC ID
L04AA26
Target and Pathway
Target(s) Tumor necrosis factor ligand superfamily member 13B Target Info [550963]
KEGG Pathway Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Intestinal immune network for IgA production
Rheumatoid arthritis
Reactome TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
WikiPathways Spinal Cord Injury
References
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
Ref 541944(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6887).
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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