Drug Information

Drug General Information
Drug ID
D03IKT
Former ID
DAP000422
Drug Name
Paramethasone
Synonyms
Cassenne; Cortiden; Dillar; Flumethone; Metilar; Parametasona; Parametasone; Paramethasonum; Paramezone; Parametasone [DCIT]; CS 1483; Dillar (TN); Parametasona [INN-Spanish]; Paramethasone (INN); Paramethasone [INN:BAN]; Paramethasonum [INN-Latin]; (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one; (6alpha,11beta,16alpha)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 16alpha-Methyl-6alpha-fluoroprednisolone; 6alpha-Fluoro-16alpha-methylprednisolone
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Approved [538461]
Diabetic macular edema [ICD9: 250, 362.01, 362.07, 362.53, 782.3; ICD10:E08-E13, E08.3, E09.3, E10.3, E11.3, E13.3, H35.8, R60.9] Phase 3 [551871]
Therapeutic Class
Antiinflammatory Agents
Company
Eli Lilly And Co
Structure
Download
2D MOL

3D MOL
Formula
C22H29FO5
Canonical SMILES
CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)F
InChI
1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1
InChIKey
MKPDWECBUAZOHP-AFYJWTTESA-N
CAS Number
CAS 53-33-8
PubChem Compound ID
5875
PubChem Substance ID
9617, 7980251, 8153630, 14805315, 29224902, 46504651, 48416380, 50064864, 50465193, 57323008, 96024431, 103589742, 104310501, 126665814, 127307276, 134222135, 134337718, 134971016, 136062799, 137005255, 160964662, 179316245, 184548300, 198940543, 223440592, 223672701, 226396369, 241093244
ChEBI ID
ChEBI:7922
SuperDrug ATC ID
H02AB05
SuperDrug CAS ID
cas=000053338
Target and Pathway
Target(s) Corticosteroid-binding globulin Target Info Binder [534951], [535929]
References
Ref 538461FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 012772.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534951Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity. J Clin Endocrinol Metab. 2000 Jan;85(1):361-7.
Ref 535929A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol. J Steroid Biochem Mol Biol. 1992 Aug;42(7):671-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.