Drug Information

Drug General Information
Drug ID
D0H2MO
Former ID
DNAP001385
Drug Name
Colforsin daropate hci
Synonyms
Adehl (TN); Adele (TN)
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Approved [526492]
Discovery agent Terminated [544574]
Company
Nippon Kayaku
Structure
Download
2D MOL

3D MOL
Formula
C27H44ClNO8
Canonical SMILES
CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)<br />C)OC(=O)CCN(C)C.Cl
InChI
1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
InChIKey
VIRRLEDAYYYTOD-YHEOSNBFSA-N
CAS Number
CAS 178925-65-0
PubChem Compound ID
444028
PubChem Substance ID
7848760, 10299470, 12014069, 14812528, 36887141, 49866039, 50835057, 57404593, 99234254, 104631165, 123120885, 135077137, 162249095, 163685803, 198949459, 241033969, 241182564, 241375531
Target and Pathway
Target(s) Cathelicidin antimicrobial peptide Target Info Modulator [527499], [536361]
KEGG Pathway Salivary secretion
Tuberculosis
Reactome ROS production in response to bacteria
WikiPathways Vitamin D Receptor Pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis
Integrated Pancreatic Cancer Pathway
SREBP signalling
References
Ref 526492Cardiovascular and adenylate cyclase stimulating effects of colforsin daropate, a water-soluble forskolin derivative, compared with those of isoproterenol, dopamine and dobutamine. Circ J. 2002 Dec;66(12):1150-4.
Ref 544574Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000192)
Ref 527499Natural products to drugs: natural product derived compounds in clinical trials. Nat Prod Rep. 2005 Apr;22(2):162-95. Epub 2005 Mar 8.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.

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