Drug Information

Drug General Information
Drug ID
D03QCW
Former ID
DAP001280
Drug Name
Interferon alfa-n1
Synonyms
Alfa-Interferon; Well-feron; Interferon alfa-n1 (USAN); Well-feron (TN)
Indication Hairy cell leukemia, malignant melanoma; Chronic myelogenous leukaemia [ICD9: 172, 202.4, 208.9, 205.1; ICD10:C43, C91-C95, C91.4, C92.1] Approved [536361], [551871]
Therapeutic Class
Antiviral Agents
Formula
C860H1353N227O255S9
CAS Number
CAS 74899-72-2
PubChem Substance ID
47206397
SuperDrug ATC ID
L03AB06
Target and Pathway
Target(s) Interferon-alpha/beta receptor Target Info Binder [535821], [538052], [538094]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Osteoclast differentiation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
Hepatitis C
Hepatitis B
Measles
Influenza A
Herpes simplex infection
Reactome Interferon alpha/beta signaling
Regulation of IFNA signaling
WikiPathways Toll-like receptor signaling pathway
Interferon type I signaling pathways
Interferon alpha/beta signaling
Regulation of toll-like receptor signaling pathway
Osteoclast Signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535821The clinical application of the interferons: a review. NSW Therapeutic Assessment Group. Med J Aust. 1992 Jun 15;156(12):869-72.
Ref 538052Therapy of hepatitis C: interferon alfa-n1 trials. Hepatology. 1997 Sep;26(3 Suppl 1):96S-100S.
Ref 538094Lymphoblastoid interferon alfa-n1 improves the long-term response to a 6-month course of treatment in chronic hepatitis C compared with recombinant interferon alfa-2b: results of an international randomized controlled trial. Clinical Advisory Group for the Hepatitis C Comparative Study. Hepatology. 1998 Apr;27(4):1121-7.

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