Drug Information

Drug General Information
Drug ID
D0P6MB
Former ID
DIB014680
Drug Name
Pexelizumab
Drug Type
Antibody
Indication Cardiovascular disorder [ICD10:I00-I99] Discontinued in Phase 3 [546778]
Company
Alexion Pharmaceuticals
Target and Pathway
Target(s) Complement C5 Target Info [528331]
KEGG Pathway Complement and coagulation cascades
Prion diseases
Pertussis
Staphylococcus aureus infection
Herpes simplex infection
Systemic lupus erythematosus
Reactome Activation of C3 and C5
Peptide ligand-binding receptors
G alpha (i) signalling events
Regulation of Complement cascade
WikiPathways Complement Activation, Classical Pathway
Human Complement System
Spinal Cord Injury
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
Complement cascade
References
Ref 546778Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010238)
Ref 528331Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients. Ann Thorac Surg. 2006 Aug;82(2):486-92.

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