Drug Information

Drug General Information
Drug ID
D0UB5A
Former ID
DIB001131
Drug Name
IC14
Drug Type
Antibody
Indication Sepsis [ICD9: 995.91; ICD10:A40, A41] Phase 2 [521741]
Target and Pathway
Target(s) Monocyte differentiation antigen CD14 Target Info [526202]
KEGG Pathway MAPK signaling pathway
NF-kappa B signaling pathway
Phagosome
Toll-like receptor signaling pathway
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Legionellosis
Amoebiasis
Tuberculosis
Transcriptional misregulation in cancer
NetPath Pathway FSH Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Beta1 integrin cell surface interactions
Endogenous TLR signaling
Alpha4 beta1 integrin signaling events
Reactome Ligand-dependent caspase activation
Toll Like Receptor 4 (TLR4) Cascade
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent TLR3/TLR4 cascade
Toll Like Receptor TLR6:TLR2 Cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6 mediated induction of TAK1 complex
WikiPathways Toll-like receptor signaling pathway
Regulation of Actin Cytoskeleton
MAPK Signaling Pathway
Vitamin D Receptor Pathway
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent cascade
Pathogenic Escherichia coli infection
Regulation of toll-like receptor signaling pathway
References
Ref 521741ClinicalTrials.gov (NCT00233207) IC14 Antibodies to Treat Individuals With Acute Lung Injury. U.S. National Institutes of Health.
Ref 526202IC14, a CD14 specific monoclonal antibody, is a potential treatment for patients with severe sepsis. J Endotoxin Res. 2001;7(4):310-4.

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