Drug General Information
Drug ID
D0V9RU
Former ID
DNC006862
Drug Name
ENIPORIDE
Drug Type
Small molecular drug
Indication Cardiac arrhythmias [ICD9: 427; ICD10:I47-I49] Discontinued in Phase 2 [546734]
Structure
Download
2D MOL

3D MOL

Formula
C14H16N4O3S
Canonical SMILES
CC1=CC(=C(C=C1C(=O)N=C(N)N)S(=O)(=O)C)N2C=CC=C2
InChI
1S/C14H16N4O3S/c1-9-7-11(18-5-3-4-6-18)12(22(2,20)21)8-10(9)13(19)17-14(15)16/h3-8H,1-2H3,(H4,15,16,17,19)
InChIKey
UADMBZFZZOBWBB-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Sodium/hydrogen exchanger 1 Target Info Inhibitor [534705]
Sodium/hydrogen exchanger 3 Target Info Inhibitor [534705]
KEGG Pathway cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Proteoglycans in cancerhsa04964:Proximal tubule bicarbonate reclamation
Protein digestion and absorption
Mineral absorption
Pathway Interaction Database Endothelins
RhoA signaling pathway
ErbB1 downstream signaling
Signaling mediated by p38-alpha and p38-betaendothelinpathway:Endothelins
Reactome Hyaluronan uptake and degradation
WikiPathways Regulation of Actin Cytoskeleton
G Protein Signaling Pathways
Glycosaminoglycan metabolism
Osteoclast SignalingWP706:SIDS Susceptibility Pathways
References
Ref 546734Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010029)
Ref 534705J Med Chem. 1998 Sep 10;41(19):3736-47.Bicyclic acylguanidine Na+/H+ antiporter inhibitors.

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