Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W4OL
|
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| Former ID |
DNC003629
|
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| Drug Name |
FK-633
|
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| Drug Type |
Small molecular drug
|
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| Indication | Restenosis [ICD10:I51.89] | Discontinued in Phase 2 | [546141] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H28N4O7
|
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| Canonical SMILES |
CC(C)C(C(=O)O)NC(=O)C(CC(=O)O)NC(=O)CCCOC1=CC=C(C=C1)C(<br />=N)N
|
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| InChI |
1S/C20H28N4O7/c1-11(2)17(20(29)30)24-19(28)14(10-16(26)27)23-15(25)4-3-9-31-13-7-5-12(6-8-13)18(21)22/h5-8,11,14,17H,3-4,9-10H2,1-2H3,(H3,21,22)(H,23,25)(H,24,28)(H,26,27)(H,29,30)/t14-,17-/m0/s1
|
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| InChIKey |
JFCXCBBSUORTNS-YOEHRIQHSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Glycoprotein IIb/IIIa receptor | Target Info | Modulator | ||
| Reactome | Platelet degranulation | ||||
| Elastic fibre formation | |||||
| PECAM1 interactions | |||||
| Molecules associated with elastic fibres | |||||
| Integrin cell surface interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| Integrin alphaIIb beta3 signaling | |||||
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |||||
| p130Cas linkage to MAPK signaling for integrins | |||||
| VEGFA-VEGFR2 Pathway | |||||
| MAP2K and MAPK activation | |||||
| References | |||||
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