Drug General Information
Drug ID	D0LK9N
Former ID	DIB000503
Drug Name	Fradafiban
Synonyms	BIBL-12; BIBU-52; BIBV-52; BIBW-103; BIBW-98
Drug Type	Small molecular drug
Indication	Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Terminated	[545962]
Company	Boehringer Ingelheim Corp
Structure		Download 2D MOL 3D MOL
Formula	C20H21N3O4
Canonical SMILES	C1(=O)N[C@@H](C[C@H]1CC(=O)O)COc1ccc(c2ccc(C(=N)N)cc2)c<br />c1
PubChem Compound ID	66000
Target and Pathway
Target(s)	Glycoprotein IIb/IIIa receptor	Target Info	Modulator	[534455]
Reactome	Platelet degranulation
	Elastic fibre formation
	PECAM1 interactions
	Molecules associated with elastic fibres
	Integrin cell surface interactions
	Syndecan interactions
	ECM proteoglycans
	Integrin alphaIIb beta3 signaling
	GRB2:SOS provides linkage to MAPK signaling for Integrins
	p130Cas linkage to MAPK signaling for integrins
	VEGFA-VEGFR2 Pathway
	MAP2K and MAPK activation
WikiPathways	Focal Adhesion
	Hematopoietic Stem Cell Differentiation
	Human Complement System
	Extracellular matrix organization
	Arrhythmogenic Right Ventricular Cardiomyopathy
	Integrin-mediated Cell Adhesion
	L1CAM interactions
	Integrin cell surface interactions
	Integrin alphaIIb beta3 signaling
References
Ref 545962	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005534)
Ref 534455	Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997Aug 19;96(4):1130-8.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.